Ophthalmic light sensitive nanocarrier systems

Polymeric nanocarrier systems for photodynamic therapy

Photodynamic therapy (PDT) is an emerging treatment modality that involves the combined action of photosensitizers (PSs) and light for treatment of solid tumor and other diseases. Although this therapeutic method has been considered as an alternative to classical cancer treatments, clinical PDT requires further advances in selectivity and therapeutic efficacy to overcome numerous shortages rela...

A photoCORM nanocarrier for CO release using NIR light.

A water-soluble nanocarrier for a photo-activated CO releasing moiety (photoCORM) that can be triggered with NIR excitation is described. This has an upconversion nanoparticle core encapsulated by an amphiphilic polymer imparting both water solubility and a hydrophobic interior containing the photoCORM trans-Mn(bpy)(PPh3)2(CO)2. Such an ensemble offers a unique strategy for CO delivery to biolo...

Mannan as a Promising Bioactive Material for Drug Nanocarrier Systems

Nanotechnological approaches in Ophthalmic delivery systems

Efficient ocular drug delivery remains a challenge for pharmaceutical scientists. Most ocular diseases are treated by topical drug application in the form of solutions, suspensions, ointment and other drug delivery devices like inserts, implants, gelling systems, etc. These conventional and novel dosage forms suffer from the problems of poor ocular bioavailability, because of various anatomical...

A light-activated surgical adhesive technique for sutureless ophthalmic surgery.

OBJECTIVE To investigate a scaffold-enhanced, light-activated bioadhesive technique as a substitute for sutures in ophthalmic surgery. CLINICAL RELEVANCE Suture use in ophthalmic surgery is technically demanding and time consuming and may be associated with serious complications such as inadvertent ocular penetration, which can result in retinal detachment and endophthalmitis. Bioadhesive sur...